Dimethyl Maleic Anhydride (DMMA), identified by CAS registry number 766-39-2, represents a cornerstone compound in modern organic synthesis, pharmaceutical research, and performance materials chemistry. Structurally characterized as an alkyl-substituted cyclic anhydride, DMMA displays distinct reactivity profiles compared to unsubstituted maleic anhydride. This structural property provides exceptional advantages, specifically as a reversible protecting group for primary amines in peptide synthesis, peptide mapping, and biochemical conjugate chemistry.
From a global market perspective, the integration of DMMA within biochemistry has expanded rapidly. Its chemical framework allows for high-yield, site-specific amine acylation under mild, weakly alkaline conditions (pH 8.0–9.0). Crucially, the resulting dimethyl maleamate adduct remains stable at physiological pH ranges, yet undergoes quantitative, acid-catalyzed hydrolysis at lower pH levels (pH 4.0–6.0). This controllable reversibility is vital for therapeutic drug delivery platforms, antibody-drug conjugates (ADCs), and targeted cellular delivery architectures.
Additionally, DMMA is an essential monomer for advanced polymer engineering. Its methyl substitution limits chain propagation rates, allowing manufacturers to synthesize highly specialized, low-shrinkage optical resins, heat-resistant coatings, and high-performance crosslinking agents. As industrial applications continue to evolve, global sourcing entities increasingly seek original design manufacturers (ODMs) capable of tailoring purity, physical form, and solvent dispersion packages to precise requirements.
Our ODM synthesis protocol is designed to meet strict regulatory and technical standards:
| Specification Parameter | Standard Value Range |
|---|---|
| Chemical Name | Dimethyl Maleic Anhydride (DMMA) |
| CAS Number | 766-39-2 |
| Molecular Formula | C6H6O3 |
| Assay Purity (GC) | ≥ 99.0% (Custom grades up to 99.8%) |
| Melting Point | 92.0 °C to 96.0 °C |
| Appearance | White to off-white crystalline powder / flakes |
How leading bio-pharmaceutical and materials developers navigate supplier selection to mitigate regulatory risks and functional issues.
Even trace levels of maleic anhydride or monomethyl esters can compromise pharmaceutical conjugations. Our ODM platform features advanced multi-stage recrystallization and vacuum fractional distillation, reducing critical impurities to sub-ppm thresholds.
To eliminate dust exposure in sensitive processing zones, we offer customized physical options—including variable-sized crystalline flakes and low-dust granular formats—packaged in nitrogen-flushed moisture-barrier drums.
Entering complex chemical markets requires strong regulatory compliance. We provide complete chemical documentation, including ISO9001:2015 registries, REACH certifications, FAMI-QS audits, and comprehensive SGS testing reports.
Shandong Pulisi Chemical Co., Ltd. (Stock Code: 307785) operates a modernized chemical manufacturing infrastructure in Zibo, China. Our facilities incorporate Industry 4.0 principles, employing Distributed Control Systems (DCS) to monitor reaction heat, feed ratios, and crystal growth stages in real time. This automated oversight ensures high process consistency, eliminating batch-to-batch variation.
Additionally, supply chain resilience is a core priority. With warehousing hubs at Qingdao Port, Tianjin Port, and major Xinjiang border crossings (including Alashankou and Khorgos), we provide streamlined logistics options for global destinations. By maintaining pre-positioned inventory near major ports, we reduce standard shipping lead times and protect clients against global logistics challenges.
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Explore how Dimethyl Maleic Anhydride and associated chemical products are integrated across global industries.
High-quality compounds manufactured and supplied to international markets, backed by certified quality management.
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Our operations are backed by verified audits, international standards, and global supply certifications.
Our integration of chemical processing, strict quality assurance, and international logistics serves global buyers.
We regularly export chemical products to over 100 countries, meeting diverse customs regulations and handling logistics across different regions.
With over 20 years of operations, we maintain supply partnerships with more than 1,000 corporate clients globally, including Fortune 500 enterprises.
Our production facilities maintain continuous quality control, verified by ISO9001, SGS, Halal, Kosher, and FAMI-QS certifications.
We provide stable pricing structures and customizable formulas, helping clients balance cost management with technical specifications.
Our storage warehouses near main ports allow for quick customs processing and rapid dispatch, minimizing supply chain delays.
Our technical sales team handles chemical logistics, safety compliance, and after-sales support to keep client operations running smoothly.
We regularly connect with partners at chemical trade shows worldwide to discuss collaboration and supply developments.
Commercial and technical insights about our chemical manufacturing, supply chain coordination, and customizable options.
As an original design manufacturer (ODM), we can adjust purity levels up to 99.8% for biopharmaceutical use, modify crystal particle sizes to reduce dust during processing, and supply DMMA dissolved in specific anhydrous solvent systems.
We pack moisture-sensitive anhydrides under nitrogen in composite heat-sealed bags with desiccants, all contained in heavy-duty drums. We also coordinate temperature-controlled container logistics when shipping to regions with high humidity or heat.
Yes, we can apply custom branding and labeling. We ensure all packaging displays clear GHS classifications, safety statements, hazard pictograms, and custom identifiers required by your facility.
We provide standard transaction terms, including Telegraphic Transfer (T/T), Letter of Credit (L/C), Documents Against Payment (D/P), and Open Account (O/A) structures, subject to credit review and regional risk assessments.
By maintaining inventory at key export ports, we can complete container loading and customs clearances in 7–14 days. Lead times for custom synthesis or specific packaging depend on production schedules, which we confirm during order placement.
Every production run undergoes gas chromatography (GC), HPLC analysis, and melting point validation. We supply a batch-specific Certificate of Analysis (COA) and material traceability reports with every shipment.
Yes, we support customer quality audits. Our facilities in Zibo, Shandong Province, are open to client inspectors and third-party auditors by appointment (approximately 1.5 hours' drive from Jinan Airport).
Yes, we provide evaluation samples along with their Safety Data Sheets (SDS) to help your laboratory verify purity and performance before ordering commercial quantities.
Pulisi
